The persistent problem of bubbles in the microfluidics led to several studies conducted to overcome it. Although the oxygen plasma treatment of PDMS reduces the surface hydrophobicity for a certain period of time, the hydrophilic property of PDMS vanishes over time 1. The eminent consequence of hydrophobicity in LOCs for biological systems is the entrapment of air bubbles in microfluidic channels. However, PDMS and some other polymeric materials are intrinsically water repellant (or hydrophobic), which results in difficulties in loading and operating LOCs. Polydimethylsiloxane (PDMS) is one of the main materials, which is widely used for the fabrication of biological LOCs, due to its biocompatibility and ease of use. Lab-on-a-chip (LOC) devices significantly contribute different disciplines of science. 1 Faculty of Engineering and Natural Sciences, Sabanci University, 34956, Istanbul, Turkey
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